New construction repeatedly has uprooted this congregation, which was founded by German and Irish immigrants in 1862. In the 1970s, the congregation rejected moving to the suburbs, choosing instead to relocate to a modern sanctuary beneath the new 19-story headquarters of First National Bank (later renamed Citicorp, then Citigroup Center, and now 601 Lexington). Hugh A. Stubbins designed three interlocking buildings—the church, a skyscraper, and a six-story retail and office structure—on a full New York City block, incorporating open public space in his design. The prismatic-shaped church has twin sloped roofs reaching to the sky, symbolizing hands in prayer. The church’s modular interior is the product of preeminent designers Lella and Massimo Vignelli.

Today, SPC welcomes parishioners from across New York City, New Jersey, and Long Island. The church contains an interfaith chapel designed by artist Louise Nevelson that is open daily for public prayer and meditation. SPC and its collaborators host a weekly breakfast program, an arts-based senior center, recovery meetings, legal services for immigrants, and jazz programs. SPC is a proud Sanctuary Congregation that helps protect refugees and undocumented immigrants from arrest and deportation.

A $250,000 National Fund grant with $621,302 in matching funds raised by the congregation contributed to the repair of the integrated skylight system, which is a significant architectural feature of the building.